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Fever of unknown origin (FUO) is a clinically challenging diagnostic problem in children and adults. Growing evidence has shown that [18F]FDG PET/CT is valuable in the diagnostic work-up of FUO since abnormal PET findings substantially increase the likelihood of achieving a definite diagnosis.
However, some differences in the definition of FUO, etiology, imaging evaluation and radiation sensitivity between the two populations (adult and pediatric) need to be considered.
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